منابع مشابه
Pyrimidine nucleoside transformations via anhydronucleosides.
The field of nucleosides has undergone rapid growth and development during the past decade'—3. Whereas, earlier studies were concerned with the development of methods for the synthesis of the nucleoside components of the nucleic acids, today several methods are available—each of which has its advantages and limitations. The host of "fraudulent" or "anomalous" nucleosides available today attests...
متن کاملHydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs.
Hydroxyurea has been shown to potentiate the anti-human immunodeficiency virus activities of 2',3'-dideoxynucleoside analogs such as didanosine. We have now evaluated in vitro the effect of hydroxyurea on the antiherpesvirus activities of several nucleoside analogs (acyclovir [ACV], ganciclovir [GCV], penciclovir [PCV], lobucavir [LBV], (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine [H2G], and...
متن کاملDecreased pyrimidine nucleoside monophosphate kinase activity in sickle erythrocytes.
We have previously shown that physiologic concentrations of hemin cause marked inhibition of several red blood cell (RBC) enzymes. Because endogenous heme content is elevated in sickle RBCs, we have examined the activity of hemin-sensitive enzymes in these RBCs. One of the hemin-sensitive enzymes, pyrimidine nucleoside monophosphate kinase (PNMK), was shown to have decreased activity in sickle ...
متن کاملThe hydrolysis of purine and pyrimidine nucleoside triphosphates by myosin.
It is well established that myosin will catalyze the hydrolysis of inosine triphosphate’ (l-3) as well as ATP. Even catalysis of inorganic triphosphate hydrolysis has been observed (4, 5).2 It has been reported recently (7) that uridine triphosphate is rapidly hydrolyzed in the presence of crystalline myosin, and previously unpublished experiments3 showed that synthetically made UTP4 is rapidly...
متن کاملAntileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.
Pseudoisocytidine, a new synthetic pyrimidine C-nucleoside, which might be considered a more stable analog of 5-azacytidine, is active in vitro and in vivo, i.p. and p.o., against various 1-beta-D-arabinofuranosylcytosine-resistant lines of mouse leukemia. This antileukemic activity is blocked by cytidine but not by deoxycytidine or thymidine.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56048-8